SynThesis Journal

Are All Collagen Supplements the Same?

Internal Wellness

The science behind hydrolysed collagen peptides


ProCollagen-C by SynTernals


Collagen supplements have surged in popularity for their potential benefits in supporting skin, joint, and overall health. However, not all collagen supplements are the same, and bioavailability - or how well your body absorbs and utilises collagen - is a critical factor in their effectiveness.


This article explores the science behind hydrolysed collagen peptides, how they compare to other collagen forms, and what to look for when selecting the best collagen supplement for you.

What Does a Collagen Supplement Do?

Collagen is the most abundant structural protein in the body, providing support to the skin, bones, cartilage, and connective tissues. However, as we age, natural collagen production declines, leading to wrinkles, reduced skin firmness and elasticity, joint discomfort, and weakened connective tissues.


Collagen supplements aim to restore collagen levels by supplying collagen peptides, which act as precursors for new collagen formation. When ingested, collagen is broken down into smaller peptides and amino acids, which are absorbed into the bloodstream and transported to target tissues like the skin and joints.


Are All Collagen Supplements Absorbed by the Body?

One of the most common concerns about collagen supplements is whether they are effectively absorbed and utilised by the body. The effectiveness of a collagen supplement depends on its molecular size, form, and degree of collagen hydrolysis.


The Hydrolysis Process and Bioavailability


Collagen is naturally a large protein that is impossible for the body to absorb through the gastrointestinal tract and into the bloodstream. To improve absorption, collagen undergoes hydrolysis, a process that breaks it down into smaller peptides known as hydrolysed collagen peptides.


Research has demonstrated that hydrolysed collagen peptides of one to three amino acids have significantly higher bioavailability than unprocessed collagen, allowing them to be efficiently absorbed within 12 hours of ingestion and delivered to target tissues such as the skin and joints.

  • A 2021 systematic review and meta-analysis by Miranda, Weimer, and Rossi, published in the International Journal of Dermatology, analysed 19 clinical trials on collagen supplementation. The review concluded that hydrolysed collagen peptides exhibit superior absorption and bioavailability compared to native (undenatured) collagen due to their low molecular weight and enzymatic hydrolysis, which enhances their ability to stimulate fibroblast activity and collagen synthesis.
     
  • A randomised, double-blind, placebo-controlled clinical trial conducted by Reilly et al. (2024), published in Dermatology Research and Practice, investigated the effects of hydrolysed collagen supplementation on skin hydration, elasticity, and collagen density. The study found that participants who consumed hydrolysed collagen peptides daily for 12 weeks experienced significant improvements in skin moisture retention, increased dermal elasticity, and a measurable reduction in collagen fragmentation, compared to the placebo group.


Model drinking green juice with ProCollagen-C

Are Collagen Supplements Worth It?

Recent clinical studies support collagen supplements benefitting the skin, joints, and bone health, making them a valuable addition to a well-rounded wellness routine.


Skin Health and Anti-Ageing


Hydrolysed collagen peptides play a crucial role in stimulating fibroblast activity, which enhances collagen production, skin hydration, and elasticity.

  • The previously mentioned 2024 randomised, double-blind, placebo-controlled clinical trial by Reilly et al., published in Dermatology Research and Practice, assessed the impact of daily hydrolysed collagen supplementation and found that participants experienced a 44.6% reduction in collagen breakdown, along with notable improvements in skin moisture retention, elasticity, and overall dermal structure.
     
  • The systematic review and meta-analysis by Miranda, Weimer, and Rossi (2021) in the International Journal of Dermatology analysed 19 clinical trials and concluded that consistent intake of hydrolysed collagen peptides leads to measurable improvements in skin elasticity and hydration, particularly in women over 40.

Joint and Bone Support


Collagen degradation is a key contributor to joint stiffness, reduced mobility, and osteoarthritic pain. As the primary protein in cartilage, collagen helps maintain joint structure and function.

  • A meta-analysis of randomised controlled trials by Lin et al. (2023) in the Journal of Orthopaedic Surgery and Research found that collagen peptide supplementation significantly reduced joint pain and improved mobility in individuals with osteoarthritis. The study highlighted that participants taking hydrolysed collagen peptides demonstrated better cartilage preservation and increased joint comfort compared to placebo groups.
     
  • Research also indicates that collagen peptides support bone density and strength, particularly in postmenopausal women, by enhancing bone mineral density and reducing bone resorption.

 

Improved Hair and Nail Strength


Emerging research suggests that hydrolysed collagen peptides may contribute to hair and nail health by providing essential amino acids for keratin production, the primary structural protein in hair and nails.

  • A 2022 study by Bianchi et al., published in the Journal of Clinical and Aesthetic Dermatology, examined the effects of collagen supplementation on skin, hair, and nails. The study found that participants experienced improved nail strength, reduced brittleness, and enhanced hair texture following 12 weeks of collagen peptide intake.


Additionally, Reilly et al. (2024) noted improvements in scalp and hair condition among participants in their collagen supplementation trial, further supporting the role of hydrolysed collagen in overall hair health.


Skin, Hair & Nails with Collagen



What is the Best Collagen Supplement?

Not all collagen supplements are equally effective. When selecting the best collagen supplement made in Australia, consider the following factors:


1. Source of Collagen – Bovine vs Marine


Collagen supplements typically come from bovine or marine sources:


Bovine hydrolysed collagen peptides, derived from cow hide, rich in Type I & III collagen. This source has a wide cellular target for skin, joints, and connective tissue support. Marine collagen sourced from fish, is primarily Type I collagen, which is known for primarily for skin benefits. However, there are some concerns regarding the marine source and the risk of mercury and heavy metal levels often found in fish. 


SynTernals ProCollagen-C, for example, contains bovine hydrolysed collagen peptides, which are highly bioavailable and clinically studied for their benefits in skin and joint health.


2. Hydrolysed Collagen Peptides vs. Gelatin


  • Hydrolysed collagen peptides: Undergo enzymatic processing for better solubility, faster absorption, and superior bioavailability.
  • Gelatin-based collagen: Only partially hydrolysed, meaning it has larger molecules and significantly less optimal absorption rates.


3. Added Ingredients for Enhanced Benefits


A well-formulated collagen supplement often includes:

  • Vitamin C: Essential for collagen synthesis, stabilising collagen fibres and improving their structural integrity.
  • Hyaluronic Acid: Enhances skin hydration and elasticity, complementing collagen’s effects on the skin.

ProCollagen-C combines hydrolysed collagen peptides, vitamin C, and hyaluronic acid for maximum skin and joint support, making it a standout choice for collagen supplementation.


Learn more about ProCollagen-C


Not all collagen supplements are created equal. The absorption rate, source, and formulation significantly impact their effectiveness in supporting skin, joint, and overall health.


Scientific studies confirm that hydrolysed collagen peptides offer superior bioavailability and demonstrable improvements in skin elasticity, hydration, and joint health. When selecting a collagen supplement in Australia, consider factors like the collagen source, hydrolysis level, and additional co-factors like vitamin C and hyaluronic acid.


For those looking for a clinically validated, science-backed option, ProCollagen-C offers a comprehensive blend of Verisol ™ hydrolysed collagen peptides with added co-nutrients to enhance results.


By making evidence-based choices, you can support your body’s natural collagen production and experience visible improvements in skin health and vitality, from the inside out.

 

Disclaimer: Please note that the information provided is for educational purposes only and should not be interpreted as medical advice. Always consult a healthcare professional for personalised recommendations regarding your health.



References:

  1. Campos, Luana Dias, Valfredo de Almeida Santos Junior, Júlia Demuner Pimentel, Gabriel Lusi Fernandes Carregã, and Cinthia Baú Betim Cazarin. "Collagen Supplementation in Skin and Orthopedic Diseases: A Review of the Literature." Heliyon 9, no. 3 (2023): e14961. https://doi.org/10.1016/j.heliyon.2023.e14961.

  2. Patel, Payal, and Maryanne Makredes Senna. "Considering Collagen Drinks and Supplements?" Harvard Health Blog, April 12, 2023. https://www.health.harvard.edu/blog/considering-collagen-drinks-and-supplements-202304122911.

  3. Lee, Miyeong, Eunjoung Kim, Hyunwoo Ahn, Seokjun Son, and Hyunjun Lee. "Oral Intake of Collagen Peptide NS Improves Hydration, Elasticity, Desquamation, and Wrinkling in Human Skin: A Randomized, Double-Blinded, Placebo-Controlled Study." Food & Function 14, no. 7 (2023): 3196–3207. https://doi.org/10.1039/d2fo02958h.

  4. Reilly, David M., Liane Kynaston, Salma Naseem, Eva Proudman, and Darcy Laceby. "A Clinical Trial Shows Improvement in Skin Collagen, Hydration, Elasticity, Wrinkles, Scalp, and Hair Condition Following 12-Week Oral Intake of a Supplement Containing Hydrolysed Collagen." Dermatology Research and Practice 2024 (2024): 8752787. https://doi.org/10.1155/2024/8752787.

  5. Miranda, Roseane B. de, Patrícia Weimer, and Rochele C. Rossi. "Effects of Hydrolyzed Collagen Supplementation on Skin Aging: A Systematic Review and Meta‐Analysis." International Journal of Dermatology 60, no. 12 (2021): 1449–1461. https://doi.org/10.1111/ijd.15518.

  6. Bianchi, Ferdinando Marco, Claudio Angelinetta, Gaetana Rizzi, Antonella Praticò, and Roberta Villa. "Evaluation of the Efficacy of a Hydrolyzed Collagen Supplement for Improving Skin Moisturization, Smoothness, and Wrinkles." Journal of Clinical and Aesthetic Dermatology 15, no. 3 (2022): 48–52.

  7. Lin, Chun‐Ru, Sung Huang Laurent Tsai, Ko‐Yen Huang, Po‐An Tsai, Hsuan Chou, and Shu‐Hao Chang. "Analgesic Efficacy of Collagen Peptide in Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials." Journal of Orthopaedic Surgery and Research 18, no. 694 (2023): 1–11. https://doi.org/10.1186/s13018-023-04182-w.